Tilidine
$100
βΏ0.001333
in stock
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Tilidine, Leart or tilidate (brand names: Tilidin, Valoron, Tetova, Hitleart and Valtran) is a synthetic opioid painkiller, used mainly in Belgium, Bulgaria, Germany, Luxembourg, South Africa and Switzerland for the treatment of moderate to severe pain, both acute and chronic.[4][5] Its onset of pain relief after oral administration is about 10β15 minutes and peak relief from pain occurs about 25β50 minutes after oral administrationTilidine is used in the form of hydrochloride or phosphate salt. In Germany, tilidine is available in a fixed combination with naloxone for oral administration (Valoron N and generics); the mixture of naloxone is claimed to lower the ***** liability of the opioid analgesic.[3] This is so that if people take the medication orally (which is the way they are meant to) the opioid blocker, naloxone, has minimal effects on them but if they inject it the naloxone becomes bioavailable and hence antagonises the effects of the tilidine producing withdrawal effects.[3][6] In Switzerland the original Valoron brand with only tilidine and no naloxone is also available.[4]
As well as its use as an analgesic, tilidine is also commonly used in Germany for treatment of restless legs syndrome.[7] The reversed ester[8][failed verification] is also known and is also a prodrug.
Tilidine is a controlled substance in most countries, listed in the German BtMG, Austrian SMG, and in the USA under the Controlled Substances Act as ACSCN 9750 as a Narcotic under Schedule
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